Clinical characteristics and outcome of patients admitted during the first and second waves of COVID-19 pandemic at a Tertiary Hospital in Lagos, Nigeria

Iorhen Ephraim Akase; Patricia Eyanya Akintan; Erereoghor Otrofanowei; Oluwarotimi Bolaji Olopade; Gbenga Olorunfemi; Adefolarin Opawoye; Felix M Alakaloko; Uyiekpen Emmanuel Ima-Edomwonyi; Yeside Olubunmi Akinbolagbe; Osigwe Paul Agabi; Danladi Abraham Nmadu; Gbemileke O Akinbode; Aramide C Olasope; Adewale Ogundare; Abiola Bukunmi Bolarinwa; Oluwakemi Elizabeth Awojumobi-Otokiti; Precious J Enajeroh; Moses Karami; Christopher Imokhuede Esezobor; Yewande O Oshodi; Oluwole Ayodeji Ayotunde; Wasiu Lanre Adeyemo; Christopher O Bode

doi:10.4103/jcls.jcls_57_22

Users Online: 91

ORIGINAL RESEARCH REPORT

Year : 2023 | Volume : 20 | Issue : 1 | Page : 15-21

Clinical characteristics and outcome of patients admitted during the first and second waves of COVID-19 pandemic at a Tertiary Hospital in Lagos, Nigeria

Iorhen Ephraim Akase¹, Patricia Eyanya Akintan², Erereoghor Otrofanowei¹, Oluwarotimi Bolaji Olopade³, Gbenga Olorunfemi⁴, Adefolarin Opawoye³, Felix M Alakaloko⁵, Uyiekpen Emmanuel Ima-Edomwonyi³, Yeside Olubunmi Akinbolagbe², Osigwe Paul Agabi¹, Danladi Abraham Nmadu³, Gbemileke O Akinbode⁵, Aramide C Olasope³, Adewale Ogundare³, Abiola Bukunmi Bolarinwa⁶, Oluwakemi Elizabeth Awojumobi-Otokiti⁶, Precious J Enajeroh³, Moses Karami³, Christopher Imokhuede Esezobor³, Yewande O Oshodi⁷, Oluwole Ayodeji Ayotunde⁸, Wasiu Lanre Adeyemo⁹, Christopher O Bode¹⁰
¹ Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria
² Department of Pediatrics, College of Medicine, University of Lagos, Lagos, Nigeria
³ Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria
⁴ Division of Epidemiology and Biostatistics, University of Witwatersrand, Johannesburg, South Africa
⁵ Department of Surgery, Lagos University Teaching Hospital, Lagos, Nigeria
⁶ Department of Hematology and Blood Transfusion, Lagos University Teaching Hospital, Lagos, Nigeria
⁷ Department of Psychiatry, College of Medicine, University of Lagos, Lagos, Nigeria
⁸ Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria
⁹ Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Lagos, Nigeria
¹⁰ Department of Surgery, College of Medicine, University of Lagos, Lagos, Nigeria

Correspondence Address:
Dr. Iorhen Ephraim Akase
Department of Medicine, Infectious Diseases Unit, College of Medicine, University of Lagos, Lagos
Nigeria

Source of Support: None, Conflict of Interest: None

Check

DOI: 10.4103/jcls.jcls_57_22

Introduction: Clinical data on the differences in presentation and outcome of admitted COVID-19 patients in Nigeria are limited. This study aimed to compare the first and second waves of the COVID-19 pandemic in a Tertiary Hospital in Lagos and describe the clinical differences between the waves, the severity of COVID-19, and the mortality differences. Methods: The study was a retrospective review of the medical records of all children and adults admitted to the Lagos University Teaching Hospital (LUTH) COVID-19 Isolation and Treatment Centre during the first wave (from April 2020 to October 2020) and second wave (from December 2020 to April 2021). The clinical characteristics (including COVID severity) and outcome among admitted patients during the two waves were compared. Results: Between April 2020 and April 2021, 602 patients were admitted to LUTH for COVID-19. Patients in the first wave were significantly younger (43 vs. 54.5 years), more in number (53.8% vs. 46.2%), and had a higher proportion of health-care workers than those in the second wave (14.5% vs. 6.5%). Comorbidities were present in more than half of the patients hospitalized for COVID-19 infection (51.0%). This proportion was much higher during the pandemic's second wave (41.7% vs. 61.9%, P < 0.001). The most common comorbidity found in hospitalized patients was hypertension (37.0%). Patients admitted during the second wave had shorter stays (11 vs. 7 days) and similar mortality rates (10.2% vs. 10.8%). Conclusion: The first and second waves had comparable mortality rates though patients in the first wave were younger and there were more healthcare providers in the cohort. Patients admitted to the second wave however had more comorbidities but shorter lengths of stay which may suggest a better understanding of the infection and better outcome.

[FULL TEXT] [PDF]*

Table of Contents

Similar in PUBMED

Search Pubmed for

Search in Google Scholar for

Related articles

Citation Manager

Access Statistics

Reader Comments

Email Alert *

Add to My List *

* Requires registration (Free)

Article Access Statistics

Viewed	318

Printed	18

Emailed	0

PDF Downloaded	61

Comments	[Add]