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ORIGINAL RESEARCH REPORTS
Year : 2005  |  Volume : 5  |  Issue : 2  |  Page : 54-56

Dyslipidaemia in Type 2 Diabetes Mellitus with Metabolic Syndrome


1 Department of Medicine, College of Health Sciences, Benue State University, Makurdi, Nigeria
2 Department of Medicine, University of Benin Teaching Hospital, Benin, Nigeria
3 Department of Chemical Pathology, University of Ilorin Teaching Hospital, Ilorin, Nigeria
4 Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria

Correspondence Address:
O S Adediran
Department of Medicine, College of Health Sciences, Benue State University, Makurdi
Nigeria
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Source of Support: None, Conflict of Interest: None


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Background: Dyslipidaemia is a prominent feature of Type 2 Diabetes Mellitus (T2DM) and is usually characterized by hypertriglyceridaemia, low HDL-cholesterol and high LDL-cholesterol (especially the small dense LDL-cholesterol). It is a very important risk factor for cardiovascular events among patients with T2DM. What needs to be properly documented is whether the pattern of Dyslipidaemia is similar in both patients with Metabolic Syndrome X (MSX) and patients with only T2DM; at least among Africans. This study is aimed at determining the pattern of dyslipidaemia among patients with T2DM who had MSX and those who did not. Materials and Methods: Ninety-six patients with T2DM who had MSX and another 96 without MSX were randomly selected for the study at the Lagos University Teaching Hospital (LUTH), Lagos between April and September, 2002. MSX was determined by the presence of systemic hypertension and obesity in addition to T2DM. They were physically examined and blood samples were obtained for plasma lipid profile estimation. In addition, anthropometric indices were taken. Results: Patients with MSX had higher means of triglyceride, total cholesterol and LDL cholesterol levels (0.9 ± 0.4 vs 0.5 ± 0.3 mmol/l, 5.2 ± 1.1 vs 4.4 ± 1.1 mmol/l and 3.9 ± 0.9 vs 3.5 ± 1.2 mmol/l respectively) than the controls, <0.01. Most patients with MSX [85.4%] and controls [83.3%] had low HDL-cholesterol level, =0.98, whereas those who had hypertriglyceridaemia [2(2.1%) and 1(1%) respectively] were few, =0.96. Conclusion: In the two groups studied, the HDL-cholesterol levels were generally low while those of triglyceride and total cholesterol were normal. However, patients with MSX had higher mean values for triglyceride, total cholesterol and LDL- cholesterol than those who did not have MSX.


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